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54%) (Table 1)

Therefore, it is plausible that the increased susceptibility to disease progression and the subsequent fatal outcome in this population is related to poor angiotensin 1-7 (Ang-1-7) generation, the main peptide generated by ACE2, and probably to their inaccessibility to its anti-inflammatory effects

Taken together, these oxidant detoxification mechanisms will lead to a depletion of the GSH pool, if the oxidant exposure is greater than the ability of the cell to produce and recycle oxidized GSH

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